陈泉,女,博士,副教授。2007年毕业于中国科学技术大学生物化学与分子生物学系,获理学博士学位。2007至2009年赴美国梅奥医学院(MayoClinic)从事博士后工作,研究G蛋白偶联受体的结构和功能。2009至2011年赴南加州大学从事锌指蛋白的设计与筛选相关研究。2011年3月作为中国科技大学优秀人才引进,现任生命科学学院副教授。2009年获17多肽调控国际会议优秀博士后奖。主要研究成果发表于JournalofBiologicalChemistry,Am.J.Physiol.Endocrinol.Metab,ProteinScience等相关领域国际重要期刊。
1)工程改造转录因子并探究其在合成生物学中的应用
2)开发设计生物网络适配的生物功能器件
1、Miller,L.J.,Chen,Q.,Lam,P.C.,Pinon,D.I.,Sexton,P.M.,Abagyan,R.andDong,M.Refinementofglucagon-likepeptide1dockingtoitsintactreceptorusingmid-regionphotolabileprobesandmolecularmodeling.JournalofBiologicalChemistry,2011,Inpress
2、Chen,Q.,Pinon,D.I.,Miller,L.J.,andDong,M.Spatialapproximationsbetweenresidues6and12intheamino-terminalregionofglucagon-Likepeptide1anditsreceptor.aregioncriticalforbiologicalactivity.JournalofBiologicalChemistry,2010,285:
3、Chen,Q.,Miller,L.J.,andDong,M.RoleofN-linkedglycosylationinbiosynthesis,trafficking,andfunctionofthehumanglucagon-likepeptide1receptor.Am.J.Physiol.Endocrinol.Metab.2010,299(1):E62-8
4、Chen,Q.,Pinon,D.I.,Miller,L.J.,andDong,M.Molecularbasisofglucagon-likepeptide1dockingtoitsintactreceptorstudiedwithcarboxyl-terminalphotolabileprobes.JournalofBiologicalChemistry,2009,284:
5、Chen,Q.,Niu,X.,Xu,Y.,Wu,J.,andShi,Y.SolutionStructureandBackboneDynamicsofAF-6PDZdomain/BcrPeptideComplex.ProteinScience,2007,16:
6、Niu,X.,Chen,Q.,Zhang,J.,Shen,W.,Shi,Y.,andWu,J.InterestingstructuralanddynamicalbehaviorsexhibitedbytheAF-6PDZdomainuponBcrpeptidebinding.Biochemistry,2007,46(51):
7、Ding,H.,Xu,Y.,Chen,Q.,Dai,H.,Tang,Y.,Wu,J.,andShi,Y.SolutionstructureofhumanSUMO-3C47SanditsbindingsurfaceforUbc9.Biochemistry,2005,44(8):
8、Zhang,X.,Zhang,J.,Li,X.,Xu,J.,Huang,H.,Chen,Q.,Wu,J.,andShi,Y.Compactmoltenglobule-likestateofhUBFHMGBox1atextremelylowpH.BiochimicaetBiophysicaActa,2005,1748:66–73
9、Chen,Q.andShi,Y.ProgressinSUMOmodificationresearch.ChineseBulletinofLifeSciences,2004,16:1-6
10.Xiao,Y.,Chen,Q.,Hang,J.,Shi,Y.,Wu,J.,Hong,Y.andWang,Y.Selectiveinduction,purificationandcharacterizationofalaccaseisozymefromthebasidiomyceteTrametessp.AH28-2.Mycologia,2004,96(1):26-35